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1 article(s) from Sosson, Marilyne

Enzyme-free genetic copying of DNA and RNA sequences

Marilyne Sosson and
Clemens Richert

Beilstein J. Org. Chem. 2018, 14, 603–617, doi:10.3762/bjoc.14.47

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Graphical Abstract

Figure 1: Enzyme-free template-directed extension of an RNA primer by one nucleotide. B = nucleobase, LG = le...

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Figure 2: Oligomerization of the 2-methylimidazolide of guanosine-5'-monophosphate on a poly(C) template.

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Figure 3: Structures of backbone linkages produced in enzyme-free primer extension reactions: the phosphorami...

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Figure 4: System used for studying the template effect with all 64 possible triplets at the extension site (B...

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Figure 5: Interactions attracting the incoming nucleotide to the extension site. Besides base pairing via hyd...

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Figure 6: Three possible fates of activated nucleotides in aqueous buffer that result from hydrolysis, primer...

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Figure 7: Steps and equilibria considered in our quantitative model of chemical primer extension [34]. The model ...

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Figure 8: Binding equilibrium between mononucleotides and hairpins representing primer–template duplexes, as ...

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Figure 9: Template-directed primer extension on an RNA template performed with OAt-GMP at 1.8 mM (orange), 3....

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Figure 10: Copying of four nucleotides on an immobilized RNA duplex, as reported by Deck et al. [32].

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Figure 11: Extension cycle of aminoterminal primer with N-protected nucleotides on solid support, as described...

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Figure 12: Formation of a highly reactive methylimidazolium bisphosphate from methylimidazolides of nucleotide...

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Figure 13: ³¹P NMR spectrum (161.9 MHz) of crude MeIm-GMP in D₂O. The resonance of the imidazolium bisphosphat...

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Figure 14: Imidazolium bisphosphate as intermediate in the primer extension reaction, as described by Szostak ...

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Figure 15: Proposed steps of enzyme-free primer extension with in situ activation, using the "general condensa...

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Review

Published 12 Mar 2018

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